Senior Lead Scientist
Oxford (On-site)
Bioware – Bioware /
Full-Time /
On-site
At ONI, we are driven by a profound mission: to propel scientific discovery and combat diseases by granting everyone the ability to visualise, comprehend, and share the intricate microscopic details of life. Our revolutionary Nanoimager stands at the forefront of advancing cellular studies on a molecular level, making substantial contributions to the evolution of scientific knowledge.
We dedicate ourselves to broadening the realms of human potential, and we are actively seeking an enthusiastic and devoted Senior Lead Scientist to join our pioneering team located in Oxford. We believe in the power of relentless curiosity and the pursuit of excellence, and we invite you to join us in shaping the future of scientific exploration and healthcare breakthroughs.
The successful candidate will be responsible for supporting the development of novel kits and biochemical or biophysical tools for super resolution microscopy, leading to Life Science tool product launches that enable users to visualise and analyse biological systems on the Nanoimager platform.
Your Role at ONI:
- Conduct hands-on lab work to support development of products (~70% of time commitment)
- Manage up to three direct reports, supporting their professional and personal development (~30% of time commitment)
- Design and execute proof-of-concept experiments for novel workflows and novel products enabling super-resolution imaging of biological materials
- Test, refine and optimise new workflows for sample preparation and image acquisition protocols for use by internal & external customers
- Optimise and refine protocols and reagents to be launched as Bioware products and kits within ONI’s IP Portfolio
- Design and execute verification and validation studies for user workflow protocols
- Review and test designed protocols based on internal and external user feedback
- Support implementation of products into super-resolution workflows on the Nanoimager
- Maintain research and development records, including database management, batch records, notebooks, and all other technical documentation
- Partner with the customer-facing teams within the company to identify key user needs and propose technical solutions to customer queries and issues
- Support cross functional teams, project management, operations and manufacturing teams to enable product development leading to successful commercialization of products
- Support external partners through research collaborations to develop technical notes, application notes, webinars, and scientific publications
Essential Skills and Qualifications:
- Managed at least one full-time employee for over a year, providing direct supervision and leadership.
- Worked as part of a team to contribute to the development of successfully commercialised products used as research tools in life sciences or as diagnostics. Ideally, these are microcopy-based products.
- Developed technical concepts through product development process to verification and validation studies.
- Experience transferring products to manufacturing, developing customer-facing documentation, and supporting commercialisation/marketing efforts.
- Analysed, interpreted, presented, published research data in a rigorous peer reviewed environment, in a multidisciplinary life science team.
- Microscopy and other biophysical methods for biological research
- Assay development, optimisation, and troubleshooting
- Complex biological sample preparation and handling
- Skilled in biological chemistry, biochemistry, protein sciences, cell/subcellular systems, or Molecular biology
- Experimental design, data acquisition, data analysis.
- Hands-on laboratory skills, solving conceptual problems using multiple analytical tools, instruments and systems
- Advanced degree (PhD/DPhil) in relevant field i.e. molecular biology, biochemistry, biophysics, physics, or chemistry
- 4 years of post-graduate experience with at least 2 years of industry experience developing life science tools or diagnostics
Desired Skills and Qualifications:
- Experience in Super Resolution Microscopy
- Use of super-resolution microscopy techniques such as dSTORM, PALM, and PAINT and other imaging analysis.
- Lipid nanoparticle formulation and/or characterization
- Experience with in situ hybridization, nucleic acid detection via microscopy, or spatial biology techniques
- Bioconjugation
- Surface chemistry or consumables chip development
- Data analysis and statistical analysis tools, Python, MatLab, JMP, R etc.
- Design of Experiment (DOE)
- Assay and laboratory automation
At ONI, we understand that a fulfilling career involves more than just challenging work - it's about enjoying a well-rounded experience. When you become a part of our team, you not only contribute to groundbreaking research but also enjoy a range of benefits designed to enhance your life both inside and outside the workplace.
As an equal opportunity employer, we prioritize fairness and respect, ensuring every team member thrives regardless of their background. But that's not all - our perks include:
Competitive Compensation We recognize and reward your talent. Enjoy a competitive salary that reflects your expertise and contributions, ensuring your hard work is recognized.
28 days of annual leave plus 8 bank holidays and 4 dedicated wellbeing days.
Free Daily Lunches: Relish nutritious meals, courtesy of ONI, making your workdays delightful.
Onsite Gym Facilities: Stay active and energized with our convenient onsite gym, promoting your overall health.
Private Healthcare and Dental Coverage: Your health matters to us. Access top-notch medical and dental services, ensuring your well-being is in good hands.
Inclusive Culture: Be a valued member of our diverse, inclusive family. Your unique perspective is celebrated here, fostering a culture of mutual respect and understanding.
Cycle To Work Scheme: Embrace a sustainable commute with our cycle to work program, promoting eco-friendly travel and a healthy lifestyle.
Health Assured: Your mental health is essential. Access our comprehensive mental health support services for a balanced work-life experience.
People’s Pension: Secure your future with our pension scheme, investing in your financial well-being beyond the workplace.
Perks at Work: Enjoy exclusive discounts and deals through our perks at work program, adding value to your everyday life.
Specsavers Eyecare: Your vision matters. Benefit from our eyecare program with Specsavers, ensuring your eyes stay healthy and your vision clear.
If you are driven by innovation, eager to make a significant impact in the realm of scientific and medical research, and possess the skills and passion we are looking for, we invite you to apply and be a part of our mission to improve our understanding of the details of life.
